Title: Transient catabolic state with reduced IGF-I after antenatal glucocorticoids
Authors: Verhaeghe, Johan ×
Vanstapel, Florent
Van Bree, Rita
Van Herck, Erik
Coopmans, Willy #
Issue Date: Sep-2007
Publisher: Int pediatric research foundation, inc
Series Title: Pediatric research vol:62 issue:3 pages:295-300
Abstract: Glucocorticoid (GC) administration before preterm birth reduces neonatal morbidity but may restrain growth. Here we explored the effect of antenatal GC on nutrient substrates [glucose, FFA, amino acids (AA)], and on IGF-I and IGF-binding protein-1 (IGFBP-1). We analyzed umbilical vein (UV) plasma obtained at birth from 91 preterm newborns that received one course of GC (last exposure 1-1358 h before birth) and 49 newborns that did not. We found that recent GC exposure (-48 h) raised glucose, FFA, and AA concentrations, and the homeostasis model assessment of insulin resistance (HOMA-IR) index, but lowered IGF-I concentrations. The AA surge was greater in newborns with a birth weight z score <0 than in those with a z score >0. Although all AA were transiently increased, the increment was most robust for glutamine and alanine. Shorter duration since GC administration and lower IGF-I concentrations independently predicted AA levels. In conclusion, an antenatal course of GC elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations. These changes may explain the growth-inhibitory effects of repeated antenatal GC administration. Future research should clarify the role of IGF-I in the protein-catabolic response to GC.
ISSN: 0031-3998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pathophysiology of Pregnancy Section (-)
Laboratory of Clinical Bacteriology and Mycology
Clinical and Experimental Endocrinology
Section Woman - Miscellaneous (-)
Biomedical Quality Assurance Research Unit
× corresponding author
# (joint) last author

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