Title: Involvement of multiple functionally distinct cerebellar regions in visual discrimination: a human functional imaging study
Authors: Claeys, Kristl ×
Orban, Guy
Dupont, Patrick
Sunaert, Stefan
Van Hecke, Paul
De Schutter, Erik #
Issue Date: Oct-2003
Series Title: NeuroImage vol:20 issue:2 pages:840-54
Abstract: We investigated the contribution of the human cerebellum to cerebral function during visual discrimination using PET and fMRI. The cognitive task was a successive discrimination of shades of brown with a parametric variation of the stimulus presentation rate and a constant task difficulty. The successive color discrimination task was contrasted to a dimming detection control task, with identical retinal input but with double the number of motor responses. Three sets of activated cerebellar and cerebral regions were observed: rate-dependent and rate-independent color discrimination networks and a motor-and-detection network. The rate-dependent color discrimination network included both an anterior and a posterior activation site in lobule-VI of the two lateral cerebellar hemispheres, whereas the rate-independent network involved a bilateral activation site in lateral Crus-I. Cerebellar sites of the motor-and-detection network were located in medial lobule-V bilaterally, in the vermis, and in posterior left Crus-I and right Crus-II. An additional fMRI study was performed to control for differences in motor output and response timing between the tasks. In this control study, the cerebellar activation sites of the rate-dependent and rate-independent color discrimination networks remained unaltered. The motor-and-detection network included cerebellar activations in posterior left Crus-I and right Crus-II, but none in lobule-V or the vermis. Thus, cerebellar activation sites of the motor-and-detection network could be subdivided into those related to a motor network and those belonging to a dimming detection network. We conclude that successive color discrimination activates multiple, functionally distinct cerebellar regions.
ISSN: 1053-8119
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Muscle Diseases and Neuropathies
Nuclear Medicine & Molecular Imaging
Research Group Neurophysiology
Research Group Experimental Neurology
Laboratory for Cognitive Neurology
Translational MRI (+)
× corresponding author
# (joint) last author

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