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Title: Blood flow in human anterior temporal cortex decreases with stimulus familiarity
Authors: Vandenberghe, Rik ×
Dupont, Patrick
Bormans, G
Mortelmans, Luc
Orban, Guy #
Issue Date: Dec-1995
Publisher: Academic press inc jnl-comp subscriptions
Series Title: NeuroImage vol:2 issue:4 pages:306-13
Abstract: In this positron emission tomography investigation of human nonverbal visual memory, we determined the anatomical distribution of changes in regional cerebral blood flow (rCBF) reflecting familiarity of visual shapes. All stimuli consisted of relatively simple, abstract outlines generated by Fourier expansions. Subjects performed the same task twice, once using unfamiliar and once using familiar stimuli. The task was a modified version of delayed nonmatching-to-sample, consisting of one sample presentation prior to tracer injection and a sequence of test trials during which images were acquired. When this task was performed with familiar instead of unfamiliar stimuli, only decreases in rCBF were observed, which were localized to the left lateral anterior temporal neocortex, the left medial temporal pole, and the rostral anterior cingulate. The correlates of familiarity measured in this human brain mapping experiment may correspond with what has been measured in single neurons in monkeys. This correspondence holds both for the type and for the localization of changes.
URI: 
ISSN: 1053-8119
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
Research Group Experimental Neurology
Research Group Neurophysiology
Nuclear Medicine & Molecular Imaging
Laboratory for Cognitive Neurology
× corresponding author
# (joint) last author

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