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Title: Dynein arms and spokes after ciliogenesis in cultured respiratory epithelial cells from non-PCD individuals
Authors: Jorissen, Mark ×
Willems, Tom
Van der Schueren, B
Verbeken, Eric #
Issue Date: Mar-2001
Series Title: Acta Oto-Rhino-Laryngologica Belgica vol:54 issue:3 pages:325-32
Abstract: Dynein arms and spokes are crucial components of cilia. Reference values for the dynein arms and spokes were calculated based on biopsies from non-PCD patients as well as after ciliogenesis in culture. The mean values in the biopsies (n = 251) were 8.4 +/- 0.5, 2.9 +/- 0.7 and 4.7 +/- 1.0 for the outer dynein arms, inner dynein arms and spokes respectively. After ciliogenesis in culture (n = 462) identical values were found: 8.7 +/- 0.4, 3.0 +/- 0.4 and 5.5 +/- 0.6. The lower limits of normality can be set at 7.0 and 1.2 for the outer and inner dynein arms respectively. The dynein arms and spokes were not influenced by the percentage of secondary abnormalities. In conclusion, dynein arms and spokes are readily identified after ciliogenesis in culture. These parameters are independent of secondary ciliary dyskinesia.
ISSN: 0001-6497
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Oto-rhino-laryngology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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