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Title: Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine
Authors: Maudgal, P C ×
Verbruggen, A M
De Clercq, Erik
Busson, Roger
Bernaerts, R
De Roo, Michel
Ameye, C
Missotten, Luc #
Issue Date: Mar-1985
Series Title: Investigative ophthalmology & visual science vol:26 issue:1 pages:45-9
Abstract: Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.
ISSN: 0146-0404
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Faculty of Medicine - miscellaneous
Medicinal Chemistry (Rega Institute)
Alumni, Faculty of Medicine
× corresponding author
# (joint) last author

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