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Title: Corneal epithelial dysplasia after trifluridine use
Authors: Maudgal, P C ×
Van Damme, Boudewijn
Missotten, Luc #
Issue Date: May-1983
Series Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie vol:220 issue:1 pages:6-12
Abstract: Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3-4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.
ISSN: 0721-832X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Alumni, Faculty of Medicine
× corresponding author
# (joint) last author

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