|Title: ||The diagnosis and management of rectal cancer: expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007|
|Authors: ||Van Cutsem, Eric ×|
De Gramont, A.
Van de Velde, C.
Zalcberg, J. #
|Issue Date: ||Jun-2008 |
|Publisher: ||Kluwer Academic Publishers|
|Series Title: ||Annals of Oncology vol:19 issue:Suppl.6 pages:Ai1-Ai8|
|Abstract: ||Knowledge of the biology and management of rectal cancer continues to improve. A multidisciplinary approach to a patient with rectal cancer by an experienced expert team is mandatory, to assure optimal diagnosis and staging, surgery, selection of the appropriate neo-adjuvant and adjuvant strategy and chemotherapeutic management. Moreover, optimal symptom management also requires a dedicated team of health care professionals. The introduction of total mesorectal excision has been associated with a decrease in the rate of local failure after surgery. High quality surgery and the achievement of pathological measures of quality are a prerequisite to adequate locoregional control. There are now randomized data in favour of chemoradiotherapy or short course radiotherapy in the preoperative setting. Preoperative chemoradiotherapy is more beneficial and has less toxicity for patients with resectable rectal cancer than postoperative chemoradiotherapy. Furthermore chemoradiotherapy leads also to downsizing of locally advanced rectal cancer. New strategies that decrease
the likelihood of distant metastases after initial treatment need be developed with high priority. Those involved in the care for patients with rectal cancer should be encouraged to participate in well-designed clinical trials, to increase the evidence-based knowledge and to make further progress. Health care workers involved in the care of rectal cancer patients should be encouraged to adopt quality control processes leading to increased
|Publication status: ||published|
|KU Leuven publication type: ||IT|
|Appears in Collections:||Laboratory of Experimental Radiotherapy|
Translational Research in GastroIntestinal Disorders
Clinical Digestive Oncology (+)