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Title: Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Authors: Van Damme, Philip ×
Van Hoecke, Annelies
Lambrechts, Diether
Vanacker, Peter
Bogaert, Elke
Van Swieten, John
Carmeliet, Peter
Van Den Bosch, Ludo
Robberecht, Wim #
Issue Date: Apr-2008
Publisher: Rockefeller Institute Press
Series Title: Journal of Cell Biology vol:181 issue:1 pages:37-41
Abstract: Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified in patients with FTLD until now have been null mutations. However, it remains unknown whether PGRN protein levels are reduced in the central nervous system from such patients. The effects of PGRN on neurons also remain to be established. We report that PGRN levels are reduced in the cerebrospinal fluid from FTLD patients carrying a PGRN mutation. We observe that PGRN and GRN E (one of the proteolytic fragments of PGRN) promote neuronal survival and enhance neurite outgrowth in cultured neurons. These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration.
URI: 
ISSN: 0021-9525
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Vesalius Research Centre (-)
Molecular and Vascular Biology
Laboratory for Neurobiology (Vesalius Research Center)
Laboratory of Translational Genetics (Vesalius Research Center) (+)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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