Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides
Lougiakis, Nikolaos × Marakos, Panagiotis Pouli, Nicole Balzarini, Jan #
Pharmaceutical Society of Japan
Chemical & Pharmaceutical Bulletin vol:56 issue:6 pages:775-780
The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.