ITEM METADATA RECORD
Title: Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides
Authors: Lougiakis, Nikolaos ×
Marakos, Panagiotis
Pouli, Nicole
Balzarini, Jan #
Issue Date: Jun-2008
Publisher: Pharmaceutical Society of Japan
Series Title: Chemical & Pharmaceutical Bulletin vol:56 issue:6 pages:775-780
Abstract: The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.
URI: 
ISSN: 0009-2363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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