Title: The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity
Authors: Gevaert, Thomas
Everaerts, Wouter
Owsianik, Grzegorz
Nilius, Bernd
De Ridder, Dirk #
Issue Date: Sep-2008
Publisher: Elsevier science bv
Host Document: European urology supplements vol:7 issue:3 pages:264-264
Conference: EAU location:Milan date:march 2008
Abstract: Background
Autonomous contractile activity (ACA) is a well-known phenomenon in isolated bladders from different species and seems to be important in the physiology of both normal and dysfunctional voiding.

To determine whether ACA is changed in bladders from paraplegic rats at different periods post–spinal cord injury (post-SCI).

Design, setting, and participants
ACA was studied in bladders (at least six per group) from normal and paraplegic female Wister rats at different times post-SCI (2 h, 24 h, 1 wk, and 3 wk). A group of normal rats was used as a control group. For measurements bladders were incubated in organ baths under standardised conditions.

ACA was measured as pressure change, which was defined as either a transient change or a spiked change according to its characteristics. The effects of intravesical volume load and muscarinic agonists were studied.

Results and limitations
Following spinal cord injury (SCI) a clear evolution in ACA was observed. In bladders from SCI rats in the acute areflexive voiding phase (1 wk post-SCI), we observed decreased ACA associated with a highly increased compliance and a changed response to muscarinic agonists. ACA in bladders from SCI rats with renewed voiding reflexes (3 wk post-SCI) was increased, together with a moderately increased compliance and a (moderately) changed response to muscarinic agonists.

From these observations it is apparent that SCI leads to alterations in the behaviour and muscarinic response of ACA in the isolated bladder. These changes in ACA may play an important role in the pathophysiology of overactive bladder disease (OAB), and interacting with changed ACA might be promising in the search for newer treatments for OAB.
ISSN: 1569-9056
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Urology Section (-)
Physiology Section (-)
Laboratory of Ion Channel Research
Screening, Diagnostics and Biomarkers (-)
Department of Cellular and Molecular Medicine - miscellaneous
# (joint) last author

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