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Title: Fate of collagen-based implants used in pelvic floor surgery: A 2-year follow-up study in a rabbit model
Authors: Claerhout, Filip ×
Verbist, Godelieve
Verbeken, Eric
Konstantinovic, Maja
De Ridder, Dirk
Deprest, Jan #
Issue Date: Jan-2008
Publisher: Mosby-elsevier
Series Title: American journal of obstetrics and gynecology vol:198 issue:1 pages:94.e1 -94.e6
Abstract: OBJECTIVE: The purpose of this study was to compare the long-term host response to 2 different collagen matrices versus macroporous polypropylene mesh. STUDY DESIGN: Four full-thickness abdominal wall defects in 35 rabbits were reconstructed with either polypropylene (Prolene), porcine dermal (Pelvicol), or small intestine submucosal collagen matrix (SIS). Animals were sacrificed on day 30, 60, 90, 180, 365, 540, and 720 days to evaluate morphologic and biomechanical properties of explants. RESULTS: Prolene provoked a fibrotic reaction within 30 days. SIS was entirely replaced by a thin fibrotic layer within 60 days. Pelvicol was encapsulated, remaining structurally unchanged up to 180 days. Thereafter, half underwent degradation by a foreign body reaction. CONCLUSION: Prolene was integrated by an increasingly organised fibrotic scar while SIS was entirely remodelled within 60 days. Pelvicol implants underwent late onset (>= 180 days) degradation. After 2 years of implantation there were no differences in tensiometric strength between the 3 different materials.
URI: 
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Urology Section (-)
Translational Cell & Tissue Research
Section Woman - Miscellaneous (-)
× corresponding author
# (joint) last author

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