Title: Novel lipophilic hydroxyurea derivatives: synthesis, cytostatic and antiviral activity evaluations
Authors: Perković, Ivana ×
Butula, Ivan
Zorc, Branka
Hock, Karlo
Pavelić, Sandra Kraljević
Pavelić, Kresimir
De Clercq, Erik
Balzarini, Jan
Mintas, Mladen #
Issue Date: Jun-2008
Publisher: Blackwell Munksgaard
Series Title: Chemical Biology & Drug Design vol:71 issue:6 pages:546-553
Abstract: The novel hydroxyurea derivatives of l- and d-amino acid amides 5a-l were prepared by aminolysis of N-(1-benzotriazolecarbonyl)-amino acid amides 4a-f with O-benzylhydroxylamine and N-methylhydroxylamine and evaluated for their antiviral and cytostatic activity against malignant tumor cell lines and normal human fibroblasts. Compounds 5a, 5c, 5e and 5k showed the highest antiproliferative effects against all tumor cell lines tested. The strongest non-specific cytostatic activities against HeLa cells were affected by compounds 5a, 5c, 5e and 5k on MCF-7 cells by 5c, 5e and 5k and MIA PACa-2 cells by 5c and 5k. Differential effects at micromolar concentrations were observed for compounds 5a, 5c, 5e, 5k and 5l in Hep G2 cells, for compounds 5c, 5e, 5k and 5l in PC-3 cells and for compounds 5e, 5k and 5l in SW 620 cells.
ISSN: 1747-0277
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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