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Title: Selective estrogen-receptor modulators and aromatase inhibitors: promising new medical therapies for endometriosis?
Authors: Simsa, Peter ×
Mihalyi, Attila
Kyama, Cleophas
Mwenda, Jason
Fülöp, Vilmos
D'Hooghe, Thomas #
Issue Date: 2007
Publisher: Future Medicine Ltd.
Series Title: Women's Health vol:3 issue:5 pages:617-628
Abstract: Endometriosis is an estrogen-dependent disease and estrogen-related pathways are imbalanced in women with endometriosis. One of the key enzymes in estrogen synthesis is aromatase. Inhibiting this pathway at several points is a promising idea for the treatment of endometriosis. The third generation of aromatase inhibitors is becoming more potent in efficacy, with fewer side effects than previous generations, but cotreatment with other hormones is needed to inhibit ovarian stimulation. Other components that promote estrogen synthesis such as COX-2 can also be potentially targeted. Selective estrogen-receptor modulators could also be interesting in view of their tissue-specific effect. However, all these new drugs are still in an early phase of development. At present, it is too early to conclude that aromatase inhibitors, COX-2 inhibitors or selective estrogen-receptor modulators really present any added value compared with the existing drugs that can be used to achieve hormonal suppression in the medical treatment of endometriosis.
ISSN: 1745-5057
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Reproductive Medicine Section (-)
Section Woman - Miscellaneous (-)
Assisted Reproductive Technology Laboratory (-)
× corresponding author
# (joint) last author

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