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Title: Trisomy 6 is the hallmark of a dysplastic clone in bone marrow aplasia
Authors: La Starza, R ×
Matteucci, C
Crescenzi, B
Criel, A
Selleslag, D
Martelli, M F
Van den Berghe, Herman
Mecucci, Christina #
Issue Date: Aug-1998
Series Title: Cancer genetics and cytogenetics vol:105 issue:1 pages:55-9
Abstract: Clonal hematopoiesis with trisomy 6 as the sole karyotypic change was revealed by cytogenetics in two cases of aplastic anemia. In both patients, dyserythropoiesis was characterized by asynchrony of maturation between nucleus and cytoplasm, binucleated elements, and intercytoplasmic connections. In addition to conventional cytogenetics, the size of the trisomic clone was evaluated by fluorescence in situ hybridization on fixed cells at diagnosis and in the course of the disease by using an alpha-satellite centromeric probe for chromosome 6. Moreover, in situ hybridization on bone marrow smears showed that dysplastic erythrocytes as well as myeloid cells belonged to the trisomic clone. Trisomy 6 identifies a subgroup of hematologic disorders with bone marrow hypo-aplasia and dyserythropoiesis.
URI: 
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
Clinical Genetics
× corresponding author
# (joint) last author

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