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Title: [Cytogenetic analysis of hypophyseal adenoma. Study of 9 cases and review of the literature]
Other Titles: Analisi citogenetica degli adenomi ipofisari. Studio di 9 casi e revisione della letteratura
Authors: Buonamici, L ×
Roncaroli, F
Frank, G
Dal Cin, Paola
Van den Berghe, Herman
Calbucci, F
Eusebi, V #
Issue Date: Apr-1998
Series Title: Pathologica vol:90 issue:2 pages:116-9
Abstract: INTRODUCTION: To the best of our knowledge, no specific chromosomal abnormalities have been found in the literature in pituitary adenomas. In the present study, we investigated 9 cases of pituitary adenoma and reviewed the current literature. MATERIALS AND METHODS: Nine cases of pituitary adenoma have been studied with immunohistochemistry and cytogenetic using short-term cultures. RESULTS: All tumors had a normal karyotype. Three cases were clinically non-secreting adenomas, three cases produced prolactin, two showed growth hormone production and one thyroid-stimulating hormone. One of the cases showed dural invasion. CONCLUSIONS: We compared our results with those published in the current literature. It appears that pituitary adenomas do not have specific numerical and structural abnormalities and mostly show a normal karyotype.
URI: 
ISSN: 0031-2983
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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