ICAAC edition:40th location:Toronto date:17-20 September 2000
METHODS: Strains isolated from blood or CSF were sent to the national reference laboratory by more than 100 labs for serotyping (SGT) (Danish Typing system) and susceptibility testing (NCCLS).RESULTS: Among the 4006 pneumococci, 254 (6.3%) were isolated from CSF and 3752 (93.7%) from blood. Thirty-four of the 46 currently identified SGTs were represented. The 8 most common SGTs accounted together for 2748 (68.6%) of the isolates. Of these 2748 patients, clinical outcome information was available for 1753 patients. Overall case fatality rate was 12.5% (220 of 1753). Pen-I and Pen-R strains among the 8 SGTs varied between 0.3 and 30.7% [table: see text]. Conclusion: SGTs 3 and 9 were relatively more frequently isolated from blood and CSF of elderly patients than the remaining 6 SGTs (p<0.001) and were associated with a significantly higher case fatality rate (p<0.01). It remains to be established whether this age-distribution is linked to the capsule type or to a specific clone.