Title: Contribution of Recent Transgenic Models and Transcriptional Profiling Studies to our Understanding of the Mechanisms by which Androgens Control Spermatogenesis
Authors: Verhoeven, Guido ×
Denolet, Evi
Swinnen, Johan
Willems, Ariane
Claessens, Frank
Saunders, Philippa T.K.
Sharpe, Richard M.
De Gendt, Karel #
Issue Date: Mar-2008
Publisher: Bentham Science Publishers
Series Title: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry vol:8 issue:1 pages:2-13
Abstract: Abstract: Androgens play a key role in the control of spermatogenesis and interference with their intratesticular secretion and action is a
critical element in many contraceptive strategies. Nonetheless, the cellular and molecular mechanisms by which androgens control germ
cell development remain poorly understood. Recent transgenic models in which the androgen receptor (AR) is selectively ablated in Sertoli
cells show unambiguously that the Sertoli cell is the main target for androgen action in the control of spermatogenesis. A number of
additional mouse models have been developed mimicking human diseases in which mutations of the AR cause disturbed fertility without
affecting male development. Transcriptional profiling studies in mice with Sertoli cell-selective AR ablation and in some other experimental
paradigms have tried to identify androgen-regulated genes relevant to the control of spermatogenesis. The overlap in genes identified
in different studies is poor but this may be due mainly to dissimilarities in experimental setup. In all studies, relatively large numbers
of genes rather than a few key genes seem to be affected by androgen action. Genes related to tubular restructuring, cell junction dynamics,
cytoskeleton, solute transportation and vitamin A metabolism are prominently present. Although further work is obviously needed, it
may be anticipated that these studies will result in the identification of subsets of genes that can be used as diagnostic tools as well as in
the identification of targets for the development of novel contraceptives
ISSN: 1871-5222
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Biochemistry Section (Medicine) (-)
Laboratory of Molecular Endocrinology
Laboratory of Lipid Metabolism and Cancer (+)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.