Title: Androgens and bone
Authors: Vanderschueren, Dirk ×
Gaytant, Jemima
Boonen, Steven
Venken, Katrien #
Issue Date: Jun-2008
Series Title: Current Opinion in Endocrinology Diabetes and Obesity vol:15 issue:3 pages:250-4
Abstract: PURPOSE OF REVIEW: The present review will focus on the most important recent findings with respect to skeletal androgen action. Many studies have indicated that part of the androgen action may be related to the conversion of androgens into estrogens. Therefore, some of the most recent findings of skeletal estrogen action relevant for male skeletal physiology will also be discussed. RECENT FINDINGS: Androgens and estrogens stimulate bone formation and inhibit bone resorption. Sex steroids may interact with different receptors, target cells and other bone anabolic pathways. Androgen receptor and estrogen receptor signalling appear to be important for male bone formation during growth. Sex steroid signalling may involve genomic and nongenomic pathways, interaction with mechanical loading, the growth hormone/insulin-like growth factor-I axis and/or other bone anabolic pathways. Estrogen receptor alpha in osteoclasts appears to regulate bone resorption in women but not men, whereas androgen receptor signalling in osteoblasts may only partly regulate bone resorption in males. SUMMARY: The latest developments indicate that androgens and estrogens are important for male bone metabolism and homeostasis and therefore selective estrogen receptor alpha and androgen receptor signalling remain interesting drug targets for the stimulation of bone formation and male skeletal integrity.
ISSN: 1752-296X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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