Title: Visual pathway glioma in children treated with chemotherapy
Authors: Demaerel, Philippe ×
de Ruyter, Nele
Casteels, Ingele
Renard, Marleen
Uyttebroeck, Anne
Van Gool, Stefaan #
Issue Date: Oct-2002
Series Title: European Journal of Paediatric Neurology vol:6 issue:4 pages:207-12
Abstract: Visual pathway gliomas occur predominantly in young children. Chemotherapy has been increasingly used as a first-line treatment because of the complications caused by radiotherapy and surgery. Nine children between 6 months and 9 years (median age of 4.8 years) were treated with vincristine and carboplatin according to the SIOP (Société Internationale d'Oncologie Pédiatrique) low-grade glioma 1996 protocol. Five patients had evidence of neurofibromatosis type 1.Magnetic resonance imaging (MRI) and ophthalmological assessment were performed during and after treatment. There was a positive response in all children (100%). Three patients developed progressive disease between 8 and 12 months after ceasing treatment. One of them, being only 2.5 years old, was again treated by chemotherapy with partial response on MRI. Patients with neurofibromatosis type 1 never developed progressive disease. Our data suggest that chemotherapy is an effective treatment option in young children with visual pathway gliomas. MRI is an important means of monitoring the tumour response provided that a rigid imaging protocol is used to detect the early tumoral changes.
ISSN: 1090-3798
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Research Group Ophthalmology
Laboratory of Clinical Immunology
Laboratory of Pediatric Immunology
Translational MRI (+)
× corresponding author
# (joint) last author

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