European Congress of Clinical Microbiology and Infectious Diseases edition:13th location:Glasgow, UK date:10-13 May 2003
Foreign body-associated infections (FBI) are a major cause of morbidity and mortality. During FBI, an initial adhesion of the bacteria is followed by accumulation and biofilm formation. The atIE encodes glucosamidase and amidase involved in peptidoglycan cleavage during cell division in Staphylococcus epidermidis. AtIE-negative mutants have a reduced virulence in in vivo models for FBI and a decreased adhesion to polystyrene in vitro. The current study aims to evaluate the expression of the atIE gene during in vitro and in vivo foreign body-associated growth.