European Drug Resistance Workshop edition:1st location:Luxembourg date:6-8 March 2003
Some studies report an increasing prevalence of resistance among recently diagnosed therapy-naïve HIV-infected patients, others a decrease. We wanted to investigate the evolution of the prevalence of primary resistance in Belgium from 1995 to 2000.
The prevalence of viral strains with NNRTI associated mutations was found to be decreasing significantly among recently diagnosed therapy-naïve Belgian patients over the period 1995-2000, as detected by LiPA. The prevalence of PI associated mutations changed significantly only when comparing patients diagnosed in 2000 to patients diagnosed in 1998. No difference was found in the prevalence of viral strains with NRTI resistance. During 1995-2000, the prevalence of strains carrying any resistance mutation, be it NRTI, NNRTI or PI mutations, remained stable in the Belgian drug-naïve patient population.