Title: Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
Authors: Jackson, Rs * ×
Creemers, John *
Farooqi, Is
Raffin-Sanson, Ml
Varro, A
Dockray, Gj
Holst, Jj
Brubaker, Pl
Corvol, P
Polonsky, Ks
Ostrega, D
Becker, Kl
Bertagna, X
Hutton, Jc
White, A
Dattani, Mt
Hussain, K
Middleton, Sj
Nicole, Tm
Milla, Pj
Lindley, Kj
O'Rahilly, S #
Issue Date: 2003
Series Title: Journal of Clinical Investigation vol:112 issue:10 pages:1550-1560
Abstract: We have previously described the only reported case of human proprotein convertase 1 (PC1) deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and reactive hypoglycemia. We now report the second case of human PC1 deficiency (Subject B), also due to compound heterozygosity for novel missense and nonsense mutations. While both subjects shared the phenotypes of obesity hypoadrenalism, reactive hypoglycemia, and elevated circulating levels of certain prohormones, the clinical presentation of Subject B was dominated by severe refractory neonatal diarrhea, malabsorptive in type. Subsequent investigation of Subject A revealed marked small-intestinal absorptive dysfunction, which was not previously clinically suspected. We postulate that PC1, presumably in the enteroendocrine cells, is essential for the normal absorptive function of the human small intestine. The differences in the nature and severity of presentation between the two cases cannot readily be explained on the basis of allelic heterogeneity, as the nonsense and missense mutations from both subjects had comparably severe effects on the catalytic activity of PC1. Despite Subject A's negligible PC1 activity, some mature ACTH and glucagon-like peptide 1(7-36amide) were detectable in her plasma, suggesting that the production of these hormones, at least in humans, does not have an absolute dependence on PC1. The presence of severe obesity and the absence of growth retardation in both subjects contrast markedly with the phenotype of mice lacking PC1 and suggest that the precise physiological repertoire of this enzyme may vary between mammalian species.
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
* (joint) first author
× corresponding author
# (joint) last author

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