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Title: Decidual differentiation of stromal cells promotes proprotein convertase 5/6 expression and lefty processing
Authors: Tang, My
Mikhailik, A
Pauli, Ilse
Giudice, Lc
Fazelabas, At
Tulac, S
Carson, Dd
Kaufman, Dg
Barbier, C
Creemers, John
Tabibzadeh, S #
Issue Date: 2005
Series Title: Endocrinology vol:146 issue:12 pages:5313-5320
Abstract: Lefty/Ebaf polypeptides, novel members of the TGF-beta superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that, during undisturbed estrous cycle, lefty is present in mouse uterine horn primarily in a precursor form. Here, we show that decidual differentiation of endometrial stroma leads to increased lefty (similar to 3.1- to 3.6-fold in vivo and 5- to 8-fold in vitro) and processing of its precursor primarily to its long form. This event occurs on d 5 of pregnancy, and is paralleled by proprotein convertase (PC)5/6 up-regulation (similar to 6-fold increase for PC5A and 3-fold increase for PC5B) in decidualized uterine horn, independent of embryo implantation. Among the known convertases, only PC5/6A processes lefty to its long form. Taken together, the findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A.
ISSN: 0013-7227
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
# (joint) last author

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