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Title: Closed spinal dysraphism: a review on diagnosis and treatment in infancy
Authors: Cornette, L ×
Verpoorten, C
Lagae, Lieven
Plets, Christiaan
Van Calenbergh, Frank
Casaer, Paul #
Issue Date: Apr-2000
Series Title: European Journal of Paediatric Neurology vol:2 issue:4 pages:179-85
Abstract: This article reviews the clinical presentation, pathophysiology, diagnostic strategies, and therapeutic management of closed spinal dysraphism in infancy. Four groups of symptoms are distinguished: (1) cutaneous abnormalities, (2) lower motor neuron dysfunction due to congenital spinal and nerve root abnormalities, (3) upper motor neuron dysfunction due to tethering of the spinal cord, and (4) symptoms caused by associated malformations. Guidelines are proposed concerning timing and type of diagnostic investigations in infancy. This essentially encompasses a neurological assessment, including spinal ultrasonography and nuclear magnetic resonance imaging of the spine and the brain, and a urological assessment, including ultrasonography of kidneys and bladder, cystourethrography and a urodynamic study. As to the tethered cord syndrome it is concluded that first, already in infancy, a progressive neurological dysfunction can be detected; second, surgical untethering should be performed only upon appearance of upper motor neuron signs or upon progression of lower motor neuron signs. Despite its frequently asymptomatic course, the diagnosis of a congenital lumbosacral lipoma, and in the more general sense, of a closed spinal dysraphism, implies a periodic, multidisciplinary follow-up for life.
ISSN: 1090-3798
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Child - Miscellaneous (-)
Research Group Experimental Neurosurgery and Neuroanatomy
Brain & Metabolism Section (-)
× corresponding author
# (joint) last author

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