Title: A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
Authors: Borasio, G D ×
Robberecht, Wim
Leigh, P N
Emile, J
Guiloff, R J
Jerusalem, F
Silani, V
Vos, P E
Wokke, J H
Dobbins, T #
Issue Date: Sep-1998
Series Title: Neurology vol:51 issue:2 pages:583-6
Abstract: To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.
ISSN: 0028-3878
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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