Title: An ocular model of Adenovirus type 5 infection in the rabbit
Authors: De Hauwere, B ×
Lutz, A
Maudgal, P C
Neyts, Johan
De Clercq, Erik #
Issue Date: 1995
Series Title: Bulletin de la Société belge d'ophtalmologie vol:259 pages:33-42
Abstract: Adenoviruses are a common cause of viral eye disease in humans. Recently, new antiviral drugs have been developed, which possess promising anti-adenovirus activity. In order to test these drugs, an ocular model of adenovirus infection was developed in 10 Hollander rabbits following topical, intrastromal and subconjunctival inoculation with a standard laboratory serotype (Adenovirus type 5 from The American Type Culture Collection). Clinical signs of infection-conjunctivitis, keratitis, corneal edema, subepithelial opacities, anterior chamber reaction and iritis-were evaluated. Adenovirus was isolated from the eye several days after inoculation and intra-epithelial viral replication was detected using the replica-technique. Reproducible ocular infection was clinically demonstrated in all rabbits.
ISSN: 0081-0746
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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