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Title: Empty sella, growth hormone deficiency and pseudotumour cerebri: effect of initiation, withdrawal and resumption of growth hormone therapy
Authors: Francois, Inge ×
Casteels, Ingele
Silberstein, J
Casaer, Paul
de Zegher, Francis #
Issue Date: May-1997
Series Title: European Journal of Pediatrics vol:156 issue:1 pages:69-70
Abstract: An 11-year-old boy with normal visus and eye fundus, but with empty sella, growth hormone (GH) deficiency and central diabetes insipidus was found to have intracranial hypertension with papilloedema after 6 months of catch-up growth under recombinant human GH (rhGH) replacement therapy. Withdrawal of rhGH therapy was associated with normalisation of intracranial pressure within 1 week. Three months later, resumption of rhGH therapy at a lower dose was again followed by pronounced growth acceleration, but now without papilloedema. CONCLUSION: Children with empty sella and GH deficiency may be prone to rhGH-induced pseudotumour cerebri which appears to be rapidly reversible and dose-dependent.
ISSN: 0340-6199
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Child - Miscellaneous (-)
Research Group Ophthalmology
Section Newborn (-)
Pediatric Hematology & Oncology Section (-)
× corresponding author
# (joint) last author

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