Title: Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver
Authors: Darras, Veerle ×
Berghman, Luc
Vanderpooten, Anita
Kühn, Eduard #
Issue Date: 10-Jul-1992
Series Title: Febs Letters vol:310 issue:1 pages:5-8
Abstract: Growth hormone (GH) increases plasma T3 and decreases plasma T4 in 18-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. The in vivo increase in T3 can be linked to an increased in vitro T3 recovery from liver homogenates incubated with T4. Specific type I and type III deiodinase tests (5'D-I and 5D-III), however, show that GH has no effect al all on the amount of hepatic type I enzyme (catalyzing T4 deiodination to T3) but acutely decreases the amount of type III enzyme (catalyzing T3 deiodination). This suggests that the GH-induced increase in plasma T3 is not due to an increased T3 production, but is the result of a decreased T3 breakdown. The lack of a stimulatory effect of GH injection in 3-day-old fed chicks might be the combined result of a low hepatic type III enzyme level and a low GH receptor availability at that stage.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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