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Title: Acute renal infarction in middle aged patients
Authors: Vanderschueren, Steven
Bolderman, R
Verrijcken, A
Knockaert, Daniel
Oyen, Raymond #
Issue Date: 11-Dec-2004
Publisher: Acta Clinica Belgica
Host Document: vol:58 issue:5 pages:318
Conference: Belgische vereniging voor inwendige geneeskunde location:Brussels, Belgium date:11 December 2004
Abstract: BACKGROUND
The 2 largest clinical series to date, each including 17 patients, suggest that renal infarction
(RI) is an infrequent disorder typically developing in the setting of cardiac disease, notably
atrial fi brillation.
HYPOTHESIS
The expanding use of computed tomography (CT) in patients with acute abdomen may
change the spectrum of RI by enabling the detection of focal abnormalities in renal parenchymal
perfusion.
METHODS
This study population includes 22 consecutive patients presenting at a single university
hospital from August 2002 to September 2004 with symptomatic non-traumatic non-iatrogenic
RI confi rmed with contrast enhanced CT. Patients were stratifi ed according to the
presence or absence of known or obvious cardiac disease processes.
RESULTS
Nine of the 22 patients (41%) had known or obvious cardiac disease at presentation, invariably
including atrial fi brillation. In 13 patients (59%), no cardiac disease was apparent at
presentation nor detected subsequently. This ‘non-cardiac’ group was younger (50 years of
age (range 44-54), median (interquartile range) versus 77 years (range 59-84), p = 0.01).
Smoking (8 of 13 patients (62%)), was the predominant traditional risk factor. Other possible
contributing factors included oral contraceptive use in 3, and combined hyperhomocysteinemia
and antithrombin defi ciency, protein S defi ciency, factor V Leiden, and arterial
dissection in 1 each. RI was often not suspected before CT revealed the diagnosis.
CONCLUSION
RI may occur in previously apparently healthy individuals of middle age. The diagnosis
should not be overlooked even in the absence of obvious risk factors for thromboembolism.
Further studies should focus on the scope of etiological investigation and on appropriate
therapeutic management strategies.
Publication status: published
KU Leuven publication type: AMa
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
Radiology
# (joint) last author

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