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Title: Protein folding diseases and neurodegeneration: Lessons learned from yeast
Authors: Winderickx, Joris ×
Delay, Charlotte
De Vos, Ann
Klinger, Harald
Pellens, Klaartje
Vanhelmont, Thomas
Van Leuven, Freddy
Zabrocki, Piotr #
Issue Date: Feb-2008
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Molecular Cell Research vol:1783 issue:7 pages:1381-1395
Abstract: Budding yeast Saccharomyces cerevisiae has proven to be a valuable model organism for studying fundamental cellular processes across the eukaryotic kingdom including man. In this respect, complementation assays, in which the yeast protein is replaced by a homologous protein from another organism, have been very instructive. A newer trend is to use the yeast cell factory as a toolbox to understand cellular processes controlled by proteins for which the yeast lacks functional counterparts. An increasing number of studies have indicated that S. cerevisiae is a suitable model system to decipher molecular mechanisms involved in a variety of neurodegenerative disorders caused by aberrant protein folding. Here we review the current knowledge gained by the use of so-called humanized yeasts in the field of Huntington's, Parkinson's and Alzheimer's diseases.
URI: 
ISSN: 0167-4889
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Genetics and Transgenesis (-)
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Laboratory for Functional Biology (-)
Associated Laboratories - miscellaneous (-)
Molecular Genetics Section (-)
Laboratory of Molecular Biology of Leukemia
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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