Title: Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
Authors: Tomassi, Cyrille ×
Nguyen, Van Nhien Albert
Marco-Contelles, José
Balzarini, Jan
Pannecouque, Christophe
De Clercq, Erik
Soriano, Elena
Postel, Denis #
Issue Date: Apr-2008
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:18 issue:7 pages:2277-2281
Abstract: The synthesis and the biological evaluation of the anti-HIV-1 activity of TSAO-Boc(3)T (8) are described. The computational analysis showed that the N-3 Boc group promotes new interactions in the binding site of the enzyme leading to a good inhibitory activity.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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