Title: ModuleMiner: improved computational detection of cis-regulatory modules. Different modes of gene regulation in embryonic development and adult tissues?
Authors: Van Loo, Peter ×
Aerts, Stein
Thienpont, Bernard
De Moor, Bart
Moreau, Yves
Marynen, Peter #
Issue Date: Apr-2008
Publisher: BioMed Central Ltd.
Series Title: Genome Biology vol:9 issue:4
Article number: R66
Abstract: ABSTRACT: We present ModuleMiner, a novel algorithm for computationally detecting cis-regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues show a strong enrichment close to the transcription start site, while CRM predictions for embryonic development gene sets are depleted in this region.
ISSN: 1474-760X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
Clinical Genetics Section (-)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Human Genome Laboratory (-)
× corresponding author
# (joint) last author

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