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Title: A double-blind comparative study of remoxipride and haloperidol in schizophrenic and schizophreniform disorders
Authors: Mendlewicz, J ×
de Bleeker, E
Cosyns, P
Deleu, G
Lotstra, F
Masson, A
Mertens, C
Parent, M
Peuskens, Joseph
Suy, E #
Issue Date: Dec-1990
Series Title: Acta psychiatrica Scandinavica. Supplementum vol:358 pages:138-41
Abstract: The antipsychotic effect of remoxipride was compared to that of haloperidol in a randomized double-blind study with parallel group design comprising 98 patients with schizophrenia or schizophreniform disorder according to DSM-III. After a 3-7 day placebo washout period, patients received either 150-600 mg of remoxipride or 5-20 mg of haloperidol daily for 6 weeks. No significant differences in efficacy were found between the two treatments. Treatment-emergent checklist symptoms such as hypokinesia, rigidity, and tremor occurred more frequently and were more severe during haloperidol than during remoxipride treatment despite a significantly higher concurrent use of anticholinergic drugs in the haloperidol group. Haloperidol-treated patients reported greater increases in sleep and salivation than remoxipride-treated patients. Shoulder shaking and tremor were reported as occurring more frequently in the haloperidol group according to the Simpson and Angus rating scale for extrapyramidal symptoms. In summary, the two drugs seemed to be equally efficacious, though the tolerability profile favoured remoxipride.
ISSN: 0065-1591
Publication status: published
KU Leuven publication type: IT
Appears in Collections:University Centre Sint Jozef (-)
Research Group Psychiatry
× corresponding author
# (joint) last author

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