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Title: New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population
Authors: Goris, An ×
Sawcer, Stephen
Vandenbroeck, Koen
Carton, Herwig
Billiau, Alfons
Setakis, Efrosini
Compston, Alastair
Dubois, Bénédicte #
Issue Date: Oct-2003
Series Title: Journal of neuroimmunology vol:143 issue:1-2 pages:65-69
Abstract: We have completed a whole genome screen for association with multiple sclerosis (MS) in a Belgian population. The 6000 microsatellite markers provided through the Genetic Association of Multiple Sclerosis in EuropeanS (GAMES) collaborative were genotyped in case-control and family-based samples. The 20 most promising markers included three markers (D6S1615, D6S2444 and TNFa) from the classically established HLA class II cluster and one (D6S265) from the recently re-emphasized HLA class I cluster. In other highlighted regions, preliminary candidate genes from the immune system have been identified: e.g. the integrin ligand EDIL3, the high-mobility group box protein TOX, neutral sphingomyelinase activating factor (NSMAF) and the B-cell specific transcription factor POU2AF1.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Faculty of Medicine - miscellaneous
Laboratory of Immunobiology (Rega Institute)
Laboratory for Neuroimmunology
× corresponding author
# (joint) last author

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