Title: Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases
Authors: Bogaert, Elke ×
Van Damme, Philip
Van Den Bosch, Ludo
Robberecht, Wim #
Issue Date: Oct-2006
Publisher: John Wiley & Sons
Series Title: Muscle & Nerve vol:34 issue:4 pages:391-405
Abstract: The angiogenic activity of vascular endothelial growth factor (VEGF) is well known. Recently, it has become evident that VEGF is involved in central nervous system physiology and may play a role in the pathogenesis of neurological diseases. In particular, it may be involved in the mechanism of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), and has been hypothesized to be implicated in the pathogenesis of peripheral neuropathies such as occur in the so-called POEMS syndrome and diabetes. VEGF is also being studied as a possible treatment option in some of these disorders. In this review we critically analyze the data supporting the notion that VEGF is a factor involved in motor neuron degeneration and review the studies linking VEGF to other diseases of the peripheral and central nervous systems.
ISSN: 0148-639X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neurobiology (VIB-KU Leuven Center for Brain & Disease Research)
× corresponding author
# (joint) last author

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