Title: Clustering of metabolic risk factors in young adults: Genes and environment
Authors: Peeters, Maarten ×
Thomis, Martine
Loos, Ruth
Derom, Cathérine
Fagard, Robert
Vlietinck, Robert
Beunen, Gaston #
Issue Date: Jan-2008
Publisher: Elsevier
Series Title: Atherosclerosis vol:200 pages:168-176
Abstract: OBJECTIVE: Evidence of a genetic basis of metabolic risk factors (MRFs) is growing. Studies examining the genetic and environmental basis of the clustering of MRFs, grouped together in the metabolic syndrome (MetS), are however sparse. The aim of this study therefore was to study the heritabilities of the MRFs and the genetic and environmental correlations between the MRFs. METHODS: Study participants were 768 Caucasian twins coming from 418 pairs (18-34 years). MRFs were those included in the National Cholesterol Education Program Adult Treatment Panel III definition of the MetS. Multivariate path analysis on the continuous MRFs of the MetS was implemented. RESULTS: Heritabilities ranged between 47.0% and 80.2% (men) and 58.5% and 77.9% (women) for the individual MRFs. Evidence was found for overarching genetic (A) and environmental (E) sources of variance, both however loading mainly on waist circumference. Furthermore, the model included a 'lipids' and a 'blood pressure'-factor both in part attributable to A and E. The majority of the variance however was MRF-specific. CONCLUSION: Based on our sample of young adults with a low prevalence of the MetS, it can be concluded that both genes and environment contribute significantly to the clustering of the MRFs although the majority of the variation is MRF-specific. Therefore, future QTL searches in young adults may want to focus on MRF-specific loci, rather than 'cluster-phenotypes' such as the MetS.
ISSN: 0021-9150
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Exercise Physiology Research Group
Department of Human Genetics - miscellaneous
Hypertension and Cardiovascular Epidemiology
Clinical Genetics Section (-)
Department of Kinesiology - miscellaneous
Physical Activity, Sports & Health Research Group
× corresponding author
# (joint) last author

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