Tijdschrift voor geneeskunde vol:62 issue:16 pages:1153-1157
General management of severe acute pancreatitis
Severe acute pancreatitis remains a very challenging disease with multiple complications and high mortality. As early identification and aggressive treatment of associated organ dysfunction can exert a major impact on outcome, early assessment of prognosis and severity is important. Supportive therapy includes vigorous hydration, analgesia, and pharmacological or mechanical support targeted towards specific organ dysfunctions. The most recent guidelines do not recommend the use prophylactic antibiotics. Enteral nutrition via a nasojejunal tube has become the preferred feeding route. The available evidence indicates that patients with severe acute pancreatitis do not benefit from a therapy with available antisecretory drugs or protease inhibitors.