Tijdschrift voor geneeskunde vol:62 issue:1 pages:1-6
Acute liverfailure: new insights
Acute or fulminant liver failure is a clinical syndrome including a sudden and severe decrease in liver function in the absence of a preexisting liver disease. It is characterised by encephalopathy, coagulopathy and metabolic problems. Acute liver failure has a high mortality. Often the only therapeutic option is emergency liver transplantation, but it is very difficult to evaluate the risk of an unnecessary transplantation versus a too late referral for transplantation. The most important prognostic criteria are still the King's College criteria, and to a lesser extent, the Clichy criteria. At this moment, there is no sufficient evidence to use (bio)artificial liver support systems as a bridge to transplantation.