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Title: Clinical relevance of thyroid fluorodeoxyglucose-whole body positron emission tomography incidentaloma
Authors: Van den Bruel, Annick ×
Maes, Alex
De Potter, Tom
Mortelmans, Luc
Drijkoningen, Maria
Van Damme, Boudewijn
Delaere, Pierre
Bouillon, Roger #
Issue Date: Apr-2002
Publisher: Issued for the Endocrine Society by the Williams & Wilkins Co.
Series Title: Journal of Clinical Endocrinology and Metabolism vol:87 issue:4 pages:1517-20
Abstract: Fluorodeoxyglucose (FDG) whole body positron emission tomography (PET) scan is increasingly used in the diagnostic work-up or follow-up of patients. In these conditions, positive PET scans with unexpected hot spots within the thyroid region could be defined as thyroid FDG-PET incidentaloma (in analogy with unexpected sonographic thyroid nodules). We describe eight consecutive patients referred to the endocrine department because of thyroid "hot spots," incidentally detected by whole body FDG-PET scan (September 1999 to March 2001). Using ultrasound, fine needle aspiration cytology (FNAC), and histology reports, we tried to identify the pathology underlying thyroid FDG-PET incidentaloma. FNAC showed an indication for surgery in all patients. Surgery has been performed in 7 patients. Malignancy was correctly identified in five patients: two medullary thyroid carcinomas, one with lymph node invasion, and three papillary thyroid carcinomas with invasion through the thyroid capsule in two of the PTC cases. In two patients with a positive FDG-PET scan, FNAC pointed to follicular neoplasms, and final histology reports showed follicular adenoma. In the remaining patient, FNAC revealed a follicular lesion, but surgery has not yet been performed. In conclusion, a small series of consecutive thyroid FDG-PET incidentaloma cases is presented and suggests a high rate of clinically relevant malignancies.
ISSN: 0021-972X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Research Group Experimental Oto-rhino-laryngology
Clinical and Experimental Endocrinology
Translational Cell & Tissue Research
Laboratory of Experimental Transplantation
Interdepartmental Platform Hospital Care
× corresponding author
# (joint) last author

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