Title: Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis
Authors: Dewil, Maarten ×
Schurmans, Céline
Starckx, Sofie
Opdenakker, Ghislain
Van Den Bosch, Ludo
Robberecht, Wim #
Issue Date: Mar-2005
Series Title: Neuroreport vol:16 issue:4 pages:321-324
Abstract: The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on the pathogenesis of amyotrophic lateral sclerosis. Although marked microglial and astroglial proliferation was seen in the spinal cord and in-vitro studies proved MMP-9 to be produced by these cells, deletion of the MMP-9 gene in SOD1(G93A) mice accelerated rather than delayed the motor neuron disease and significantly reduced survival. Our results suggest that the effect of MMP-9 on mutant superoxide dismutase-1 (SOD1)-induced motor neuron disease is protective rather than hazardous. Therefore, the effect of pharmacological inhibition of MMP-9 activity is unlikely to be of therapeutical benefit in amyotrophic lateral sclerosis.
ISSN: 0959-4965
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory of Immunobiology (Rega Institute)
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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