Title: Progesterone increases airway eosinophilia and hyper-responsiveness in a murine model of allergic asthma
Authors: Hellings, Peter ×
Vandekerckhove, Philippe
Claeys, R
Billen, Jaak
Kasran, A
Ceuppens, Jan #
Issue Date: Oct-2003
Publisher: Blackwell Scientific Publications
Series Title: Clinical and Experimental Allergy vol:33 issue:10 pages:1457-1463
Abstract: BACKGROUND: Sex hormones might affect the severity and evolution of bronchial asthma. From existing literature, there exists, however, no convincing evidence for either exacerbation or improvement of allergic symptoms by progesterone. OBJECTIVE: This study was aimed to explore the effect of exogenously administered progesterone in a mouse model of allergic asthma. METHODS: BALB/c mice were sensitized to ovalbumin (OVA) by intraperitoneal injections with OVA followed by chronic inhalation of nebulized OVA or physiologic saline (Sal). Medroxyprogesterone acetate or placebo was instilled daily into the oesophagus before and during the inhalatory OVA challenge phase. RESULTS: Progesterone worsened allergic airway inflammation in OVA-challenged mice, as evidenced by enhanced bronchial responsiveness to inhaled metacholine and increased bronchial eosinophilia. Elevated airway eosinophilia corresponded with higher bronchial and systemic IL-5 levels in the progesterone group. The ratio of IL-4/IFN-gamma levels in bronchoalveolar lavage fluid and numbers of eosinophil colony-forming units in the bone marrow were also elevated in the latter group. Progesterone, however, did not influence allergen-specific IgE production, nor did it affect bronchial responses in Sal-challenged mice. CONCLUSION: Our data show that exogenously administered progesterone aggravates the phenotype of eosinophilic airway inflammation in mice by enhancing systemic IL-5 production. Progesterone also increases bronchial hyper-reactivity.
ISSN: 0954-7894
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Bacteriology and Mycology
Research Group Experimental Oto-rhino-laryngology
Laboratory of Clinical Immunology
Department of Health and Technology - UC Leuven
Clinical and Experimental Endocrinology
Department of Public Health miscellaneous
× corresponding author
# (joint) last author

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