Title: SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis
Authors: Fenoglio, Chiara ×
Galimberti, Daniela
Ban, Maria
Maranian, Mel
Scalabrini, Diego
Venturelli, Eliana
Piccio, Laura
De Riz, Milena
Yeo, Tai Wai
Goris, An
Gray, Julia
Bresolin, Nereo
Scarpini, Elio
Compston, Alastair
Sawcer, Stephen #
Issue Date: Jan-2006
Series Title: Neuroscience Letters vol:394 issue:2 pages:92-6
Abstract: P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neuroimmunology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science