Title: Spontaneous spinal epidural hematoma associated with thrombolysis and anticoagulation therapy: report of three cases
Authors: Van Schaeybroeck, P ×
Van Calenbergh, Frank
Van de Werf, Frans
Demaerel, Philippe
Goffin, Jan
Plets, Christiaan #
Issue Date: Apr-1999
Series Title: Clinical neurology and neurosurgery vol:100 issue:4 pages:283-7
Abstract: Three patients with a spontaneous spinal epidural hematoma are presented, one of which is exceptional because it could be attributed to thrombolysis with alteplase. The other two were correlated with oral anticoagulant therapy. Our second case suggests that Morbus Kahler may be an underlying pathology in spinal extradural hematoma. In the third patient neither an obvious 'locus minoris resistentiae' nor a pathological coagulation test could be held responsible for the spontaneous bleeding. All three patients underwent laminectomy and evacuation of the hematoma. Although two of our cases are examples of complete recuperation after late operative intervention, early surgery is preferable. Permanent clinical attention together with a low threshold to perform magnetic resonance imaging (MRI) leads to a quicker diagnosis of spinal epidural hematoma. We show that administration of gadolinium may facilitate correct preoperative localization of the hematoma because there may be contrast enhancement of the hematoma. Finally, the postoperative policy concerning thromboembolic prophylaxis is discussed.
ISSN: 0303-8467
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Research Group Experimental Neurosurgery and Neuroanatomy
Translational MRI (+)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science