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Title: Positron emission tomography, magnetic resonance imaging and proton NMR spectroscopy of white matter in multiple sclerosis
Authors: Schiepers, C ×
Van Hecke, Paul
Vandenberghe, Rik
Van Oostende, S
Dupont, Patrick
Demaerel, Philippe
Bormans, Guy
Carton, Herwig #
Issue Date: Jul-1997
Series Title: Multiple sclerosis (Houndmills, Basingstoke, England) vol:3 issue:1 pages:8-17
Abstract: OBJECTIVE: To assess characteristics of MS lesions and normal appearing white matter (NAWM) with various imaging modalities. Glucose metabolism was investigated with FDG-PET, metabolite concentration with proton NMR spectroscopy, and lesion detection with routine brain MRI. METHODS: Thirteen patients were studied in a stable phase of their disease, and two during an acute episode. Nine healthy volunteers served as controls. RESULTS: Three patients had a normal brain MRI, 12 had typical lesions. MR images were registered to the PET planes. Lesions and contra-lateral control areas were analyzed, 10/15 lesions showed relative hyper-metabolism and 2 hypo-metabolism. NAA concentration was significantly decreased in both lesions and NAWM. CONCLUSION: In stable MS, most large lesions have a relatively increased glucose utilization and decreased NAA concentration. NAWM showed a significantly decreased NAA concentration compared to healthy subjects, but no difference in glucose metabolism. Active lesions in acute MS are also hyper-metabolic. This finding opens a new window on the classification of white matter lesions based on glucose utilization.
ISSN: 1352-4585
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Radiopharmaceutical Research
Faculty of Medicine - miscellaneous
Research Group Experimental Neurology
Nuclear Medicine & Molecular Imaging
Laboratory for Cognitive Neurology
Translational MRI (+)
× corresponding author
# (joint) last author

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