Title: Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium
Authors: Agu, Remigius U ×
Vu Dang, H
Jorissen, Mark
Kinget, Renaat
Verbeke, Norbert #
Issue Date: May-2004
Series Title: Peptides vol:25 issue:4 pages:563-9
Abstract: The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were investigated in human nasal epithelium. Co-administration of the peptide with protease inhibitors and absorption enhancers resulted in a remarkable increase in Met-Enk permeation (4- to 94-fold). The increase was proportional to transepithelial resistance reduction and permeation of paracellular marker dye. Perturbation of the epithelial tight junctions seen in vitro may not occur in vivo due to mucus protection and mucociliary clearance.
ISSN: 0196-9781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Research Group Experimental Oto-rhino-laryngology
× corresponding author
# (joint) last author

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