Title: Desmoplastic infantile ganglioglioma: a potentially malignant tumor?
Authors: De Munnynck, K ×
Van Gool, Stefaan
Van Calenbergh, Frank
Demaerel, Ph
Uyttebroeck, A
Buyse, Gunnar
Sciot, Raphael #
Issue Date: Oct-2002
Series Title: The American journal of surgical pathology vol:26 issue:11 pages:1515-22
Abstract: Desmoplastic infantile ganglioglioma is a rare intracranial tumor of early childhood with a usually excellent prognosis despite malignant features both radiologically and histologically. We present the case of a desmoplastic infantile ganglioglioma with histologically highly anaplastic features and both intracerebral and pial metastases. After partial resection the tumor was rapidly progressive and new metastases appeared. A combination of vincristine and carboplatinum was used according to the Low Grade Glioma Protocol of the International Society of Pediatric Oncology, with a temporary good response. When histologically characterized by highly anaplastic features, it seems the biologic behavior of this tumor remains uncertain. The aggressive behavior and the responsiveness to chemotherapy in this case may challenge the belief in the benign nature of these rare tumors.
ISSN: 0147-5185
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurosurgery and Neuroanatomy
Translational Cell & Tissue Research
Laboratory of Clinical Immunology
Brain & Metabolism Section (-)
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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