Title: Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [F-18]altanserin and positron emission tomographic imaging
Authors: Rosier, A
Dupont, Patrick
Peuskens, Joseph
Bormans, G
Vandenberghe, Rik
Maes, M
de Groot, Tjibbe
Schiepers, C
Verbruggen, Alfons
Mortelmans, Luc #
Issue Date: Nov-1996
Publisher: Elsevier sci ireland ltd
Series Title: Psychiatry research-neuroimaging vol:68 issue:1 pages:11-22
Abstract: We used [F-18]altanserin and positron emission tomography (PET) to image serotonin 5-HT2A receptors in humans. The highest [F-18]altanserin uptake is found in the cerebral cortex, with specific-to-nonspecific binding ratios varying from 0.53 to 1.91 in humans between 24 and 48 years of age. In all neocortical regions studied, [F-18]altanserin uptake correlates negatively with age. No correlations were found between age and uptake in the cerebellum, the regional cerebral blood flow, or the time course of metabolization of [F-18]altanserin. The reduction in cerebral 5-HT2A receptor binding thus directly reflects the loss of specific 5-HT2A receptors with age. Copyright (C) 1996 Elsevier Science Ireland Ltd.
ISSN: 0925-4927
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
Research Group Experimental Neurology
Nuclear Medicine & Molecular Imaging
University Centre Sint Jozef (-)
Education and Training
Research Group Psychiatry
Laboratory for Cognitive Neurology
# (joint) last author

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