Title: Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis
Authors: Vanopdenbosch, L ×
Dubois, B
D'Hooghe, M B
Meire, F
Carton, Herwig #
Issue Date: Dec-2000
Series Title: Journal of neurology vol:247 issue:7 pages:535-43
Abstract: Multiple sclerosis (MS) and Leber's hereditary optic neuropathy (LHON) have been found to occur in combination. Based on an extensive literature search and on a clinical analysis of 55 LHON pedigrees (103 patients) and 40 patients with definite MS, this study concludes that the association of LHON and MS is more than a coincidence, and that carrying a primary LHON mutation is a risk factor for developing MS. All three primary LHON mutations occurring in the European and North American populations have been found to be associated with an MS-like syndrome. The neurological characteristics of MS associated with LHON are indistinguishable from those of MS in general, but the severe and bilateral visual symptoms and signs justify considering these patients as a clinical subgroup of MS and screening them for LHON mutations. However, screening LHON patients for MS appears to be more rewarding.
ISSN: 0340-5354
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science