Tijdschrift voor psychiatrie vol:48 issue:3 pages:223-237
BACKGROUND: Late-onset depression with vascular brain lesions is showing increased resistance to antidepressive pharmacotherapy. AIM: To give an overview of alternative treatment options. METHOD: We conducted a literature search via PubMed using the key words: 'late-onset depression', 'white matter lesions', 'cerebrovascular pathology' and 'treatment' and thereby a searchfor all available clinical studies about the treatment described in combination with the key words 'vascular depression', or 'late-onset depression' and 'white matter lesions'. RESULTS: Electroconvulsive therapy, repetitive transcranial magnetic stimulation and nimodipine au,gmentation have beneficial effects on vascular depression. CONCLUSION: The treatment options mentioned are promising, but there is a need for further clinical studies.