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Title: Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys
Authors: Vanduffel, Wim ×
Fize, Denis
Mandeville, J B
Nelissen, Koen
Van Hecke, Paul
Rosen, B R
Tootell, R B
Orban, Guy #
Issue Date: Nov-2001
Series Title: Neuron vol:32 issue:4 pages:565-577
Abstract: To reduce the information gap between human neuroimaging and macaque physiology and anatomy, we mapped fMRI signals produced by moving and stationary stimuli (random dots or lines) in fixating monkeys. Functional sensitivity was increased by a factor of approximately 5 relative to the BOLD technique by injecting a contrast agent (monocrystalline iron oxide nanoparticle [MION]). Areas identified as motion sensitive included V2, V3, MT/V5, vMST, FST, VIP, and FEF (with moving dots), as well as V4, TE, LIP, and PIP (with random lines). These regions sensitive for moving dots are largely in agreement with monkey single unit data and (except for V3A) with human fMRI results. Moving lines activate some regions that have not been previously implicated in motion processing. Overall, the results clarify the relationship between the motion pathway and the dorsal stream in primates.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Research Group Neurophysiology
× corresponding author
# (joint) last author

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